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ProstateFactSheet.com
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ones. We hope that you’ll find this information about the
Prostate
and Prostate Cancer
helpful and that you’ll seek professional medical advice to address any
specific symptoms you might have related to this matter.
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What is the prostate?
What is prostate cancer?
What are the risk factors for prostate cancer?
Who should get tested for prostate cancer?
What are the symptoms of prostate cancer?
How is prostate cancer diagnosed?
What is the treatment for prostate cancer?
Where can I buy a home test kit for prostate
cancer?
What is the
prostate? (top)
The
prostate is part of a man's sex organs. It's about the size of a walnut
and surrounds the tube called the urethra, located just below the
bladder.
The urethra
has two jobs: to carry urine from the bladder when you urinate and to
carry semen during a sexual climax, or ejaculation. Semen is a
combination of sperm plus fluid that the prostate adds.
For men
under 50, the most common prostate problem is
prostatitis (Inflammation of the
prostate gland. Chronic prostatitis means the prostate gets inflamed
over and over again. The most common form of prostatitis is not
associated with any known infecting organism.)
For men over 50,
the most common prostate problem is prostate enlargement. This condition
is also called benign prostatic hyperplasia or BPH. (An enlarged
prostate not caused by cancer. BPH can cause problems with urination
because the prostate squeezes the urethra at the opening of the bladder)
Older men are at risk for prostate cancer as well, but this disease is
much less common than BPH. More information about prostate cancer is
available from the
National Cancer Institute.
What is
prostate cancer? (top)
Prostate cancer is a
malignant
tumor that begins growing in the prostate gland. It can spread from the
prostate to nearby
lymph nodes,
bones, or other organs. This spread is called
metastasis.
A male hormone called
testosterone
can stimulate the growth of hormone-dependent prostate cancer cells.
Prostate cancer is the second leading cause of cancer death in men. But
the good news is that survival rates have improved a great deal. In the
past 20 years, 5-year survival rates for all stages of prostate cancer
combined have increased from 67% to 99%.
What are the
risk factors for prostate cancer? (top)
While researchers still do not know exactly what causes
prostate cancer, they have identified some risk factors.
-
Age. The risk of developing prostate cancer
increases as you age. More than 70% of all prostate cancers are
diagnosed in men over age 65.
-
Family History. Men whose father and/or brother
had prostate cancer are up to 11 times more likely to develop prostate
cancer.
-
Ethnicity. The death rate for prostate cancer is
nearly 2.4 times higher in African-American men than in Caucasian men.
(Because of this additional risk, earlier screening for prostate
cancer is recommended for African-American men.
See below.)
-
Diet. Research suggests that prostate health may
be affected by diet.
-
Obesity. Studies have shown that the death rate
from prostate cancer increases in obese men.
Who should get
tested for prostate cancer? (top)
When should you be
tested for prostate cancer? According to the American Cancer Society,
men aged 50 and older with a life expectancy of at least 10 years, and
those over the age of 45 who are in high-risk groups (such as
African-American men and men with a family history of prostate cancer)
should have a
prostate-specific
antigen (PSA) (A protein produced by cells of the prostate
gland. PSA levels are used to help identify disorders of the prostate)
blood test and
digital rectal
exam (DRE) (The doctor inserts a gloved finger into the
rectum to feel for anything not normal. Some tumors of the rectum and
prostate gland can be felt during a DRE.) once every year
What are the symptoms
of prostate cancer? (top)
Early prostate
cancer usually does not cause any symptoms. But as the
tumor
grows it may spread from the prostate to surrounding areas causing a
variety of symptoms. As a result of
metastasis
to the spine, for example, many men experience pain in the lower back,
pelvis, or upper thighs.
-
Symptoms of more advanced cases of prostate cancer may also include:
Interruption of urinary flow (stopping and starting)
-
Inability to urinate
-
Difficulty starting or stopping urination
-
Frequent urination (especially at night)
-
Blood in the urine
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Pain or burning
during urination
How
is prostate cancer diagnosed? (top)
Several
tests help the doctor identify the problem and decide on the best
treatment.
- Digital rectal
exam. This exam is usually the first test done. The doctor inserts
a gloved finger into the rectum and feels the part of the prostate
that sits next to it. This exam gives the doctor a general idea of the
size and condition of the prostate.
- Blood test.
The doctor may want to test a sample of your blood to look for
prostate-specific antigen, or PSA. If your PSA is high, it may be a
sign that you have prostate cancer. But this test isn't perfect. Many
men with high PSA scores don't have prostate cancer.
- Imaging. The
doctor may want to get a picture of your prostate using either x rays
or a sonogram. An IVP, or intravenous
pyelogram, is an x ray of the urinary tract. For an IVP, dye
will be injected into a vein. Later, when the dye passes out of your
blood into your urine, it will show up on the x ray. A rectal sonogram
uses a probe, inserted into the rectum, to bounce sound waves off the
prostate.
- Urine flow study.
You may be asked to urinate into a special device that measures how
quickly the urine is flowing. A reduced flow may mean that you have
BPH.
- Cystoscopy.
Another way to see a problem from the inside is with a
cystoscope, which is a thin
tube with lenses like a microscope. The tube is inserted into the
bladder through the urethra while the doctor looks through the
cystoscope.
What is the
treatment for prostate cancer? (top)
There are
many choices in the treatment of prostate cancer. The main options
include
surgery,
radiation,
hormonal therapy,
chemotherapy,
and
watchful waiting.
In deciding which treatment option is most appropriate for you, you and
your doctor will consider several factors, including the cancer stage
and expected benefits and risks of treatment.
Although
prostate cancer is best treated when detected at an early stage,
therapies are available that can help even after the cancer has spread
outside of the prostate. Your doctor will determine which of these
treatments is most appropriate for you.
Surgical
Treatment for Prostate Cancer
For more
than three decades, the "gold standard" treatment for prostate cancer
has been radical prostatectomy, or removal of the prostate gland. This
option is used only if the cancer has not obviously spread beyond the
gland. Removal of the prostate gland requires a two to five day hospital
stay and a recovery period of several weeks. This surgery’s common side
effects include loss of erectile ability (impotence) and urinary leakage
(incontinence).
Refinements
to radical prostatectomy include “nerve sparing” and “bladder neck
sparing” surgeries, which may be performed in qualified patients. In
these operations, the prostate is surgically removed, but the physician
preserves the nerves necessary for erections and/or the bladder neck,
which is the outlet of the bladder. For the patient, these important
advances allow earlier return of continence after surgery and possible
preservation of erectile function. Typically hospitalization for this
procedure is two to three days, with a home recover period of three to
four weeks before resuming normal activities.
Because a
tumor frequently spreads to tissues adjacent to the prostate, removal of
the prostate does not guarantee a cure. Even the best reported surgical
results show cure in only about three our of every four prostatectomy
patients. The presence of Prostate Specific Antigens (PSA) after surgery
may indicate prostatectomy failure and the need for additional therapy,
such as external beam radiation.
External
Beam Radiation
External
beam radiation therapy kills cancer cells by decreasing their ability to
grow and divide. Many consider radiation a form of “micro-surgery”
because it has the ability to eradicate tumor cells while preserving
normal cells and tissues. Radiation usually involves seven to eight
weeks of daily treatments in which beams of radiation are directed at
the prostate gland in order to destroy the cancer cells.
The
procedure itself is painless. However, side effects such as rectal
irritation, diarrhea, frequent urination and fatigue may result from
external beam radiation. Impotence is less likely from radiation than
from surgery.
Seed Implant Therapy (Prostate Brachytherapy)
Ultrasound-guided prostate seed implant (prostate brachytherapy), a
procedure that Northwest Hospital physicians pioneered in the United
States, is one of the best treatment options for early stage prostate
cancer. The procedure involves precise placement of small, radioactive
seeds into the prostate using ultrasound guidance ? without open
surgery. By doing so, only the prostate itself is radiated, limiting the
radiation dose to nearby normal, health tissue. The radioactive seeds
implanted into the prostate gradually lose radioactivity over time,
destroying cancer cells, but sparing normal cells. With this procedure,
there is a minimal risk of impotence and incontinence.
Prostate
brachytherapy is a minimally-invasive procedure that takes approximately
45 minutes in an Outpatient Surgery Center. With seeding, patients go
home the same day and are usually back to their usual daily activities
within a day or two.
In 1998,
and again in 2000, Northwest Hospital physicians published the first
study results to report actual ten and 12-year results. These studies
showed that when followed for many years after treatment for their
early-stage prostate cancer, 66 to 69 percent of patients who received
brachytherapy were disease-free and had PSA levels comparable to
non-cancer patients. Compared to radical prostatectomy results reported
by any major cancer centers across the United States, our results with
brachytherapy were either the same or significantly better than those of
surgery. The results were also consistently much better than those of
patients who underwent only external beam radiation.
Combination Therapy
External
beam radiation is frequently used in combination with seeding. In this
situation, men who are at increased risk of cancer outside their
prostates (and hence are usually considered incurable with a radical
prostatectomy) receive treatment with both brachytherapy and an
abbreviated course of external beam therapy. Men at risk for cancer
outside their prostate may have a high PSA, advance clinical stage,
and/or high Gleason score. (A Gleason score is a method of classifying
prostate cancer cells on a scale of 2 to 10. The higher the Gleason
score the faster the cancer is likely to grow and the more likely it is
to spread beyond the prostate.) Results from seeding plus external beam
radiation in this group of “high risk” men are excellent with up to 79
percent disease-free survival observed in patients followed up for 12
years.
Hormone
Therapy
Several
different types of hormone therapy may be used to treat prostate cancer.
The goal is to reduce or stop production of male hormones that feed both
the normal prostate and the cancer. In this manner, the prostate may be
made to shrink, which is occasionally necessary for an optimum seed
implant. This therapy is usually administered as a monthly injection.
Hormone therapy is sometimes used to make tumors more responsive to
radiation.
Nutritional and Lifestyle Therapy
It has been
well established that dietary factors can have a large impact on a man’s
chance of developing prostate cancer. Likewise, nutrition and lifestyle
are important in fully combating the disease and the potential side
effects of treatment. The complex nutritional interactions with
compounds like isoflavones, selenium, lycopenes, chromium, co-enzyme
Q-10, and many more are important to regulate before, during, and after
therapy
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prostate cancer.
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